Pharmacological Properties of Stinky Ferula Gum and its Anti-Inflammatory Effects
DOI:
https://doi.org/10.31150/ajshr.v3i2.906Keywords:
Ferula tajikorum, Anti-inflammatory, amphetamine, locomotor activityAbstract
Preliminary pharmacological studies of the gum exatract of underground parts of Ferula tajikorum plant (EFT) were conducted. EFT witth LD50 5 g/kg in dose 10 mg/kg p.o. during prolonged administration decreased of spontane locomotors activity fall down to 25% and it was evaluated as sedation. In dose 30 mg/kg sedation was not stable. At a dose of 30 mg/kg sedation was unstable. Both doses enhanced amphetamine locomotor action, decreased haloperidole catalepsy and decreased arecoline M-cholinostimulating action, i.e. effects on neuroreceptors were noted. Antiinflammatory effect of a dose of 10 is more pronounced than from a dose of 30 mg/kg. Considering the literature data on a wide range of EFT pharmacological properties and the multidirectionality of the properties of EFT it is concluded that it is advisable to separate the extracts into components or fractions of structurally similar substances. This will reveal the specific activity and predictability of their practical application or use as a sample for synthesis in classdicine.
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